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SIRT1 Is a Circadian Deacetylase for Core Clock Components

The transcriptional activator CLOCK is a histone acetyltransferase that is required for the circadian expression of many genes. Asher et al. (2008) and Nakahata et al. (2008) now demonstrate that the NAD(+)-dependent enzyme SIRT1 functions as a histone deacetylase that counteracts the activity of CL...

詳細記述

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書誌詳細
主要な著者: Belden, William J., Dunlap, Jay C.
フォーマット: Artigo
言語:Inglês
出版事項: 2008
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3671948/
https://ncbi.nlm.nih.gov/pubmed/18662537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2008.07.010
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