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SIRT1 Is a Circadian Deacetylase for Core Clock Components
The transcriptional activator CLOCK is a histone acetyltransferase that is required for the circadian expression of many genes. Asher et al. (2008) and Nakahata et al. (2008) now demonstrate that the NAD(+)-dependent enzyme SIRT1 functions as a histone deacetylase that counteracts the activity of CL...
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| Main Authors: | , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2008
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3671948/ https://ncbi.nlm.nih.gov/pubmed/18662537 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2008.07.010 |
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