Specific Sirt1 Activator-mediated Improvement in Glucose Homeostasis Requires Sirt1-Independent Activation of AMPK

The specific Sirt1 activator SRT1720 increases mitochondrial function in skeletal muscle, presumably by activating Sirt1. However, Sirt1 gain of function does not increase mitochondrial function, which raises a question about the central role of Sirt1 in SRT1720 action. Moreover, it is believed that...

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Detaylı Bibliyografya
Yayımlandı:EBioMedicine
Asıl Yazarlar: Park, Sung-Jun, Ahmad, Faiyaz, Um, Jee-Hyun, Brown, Alexandra L., Xu, Xihui, Kang, Hyeog, Ke, Hengming, Feng, Xuesong, Ryall, James, Philp, Andrew, Schenk, Simon, Kim, Myung K., Sartorelli, Vittorio, Chung, Jay H.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Elsevier 2017
Konular:
Research Paper
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5405165/
https://ncbi.nlm.nih.gov/pubmed/28396013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2017.03.019
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