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Fail-safe control of translation initiation by dissociation of eIF2α phosphorylated ternary complexes
Phosphorylation of eIF2α controls translation initiation by restricting the levels of active eIF2-GTP/Met-tRNAi ternary complexes (TC). This modulates the expression of all eukaryotic mRNAs and contributes to the cellular integrated stress response. Key to controlling the activity of eIF2 are transl...
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| Vydáno v: | eLife |
|---|---|
| Hlavní autoři: | , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
eLife Sciences Publications, Ltd
2017
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5404910/ https://ncbi.nlm.nih.gov/pubmed/28315520 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.24542 |
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