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Substrate Recognition and Modification by a Pathogen-Associated Aminoglycoside Resistance 16S rRNA Methyltransferase
The pathogen-associated 16S rRNA methyltransferase NpmA catalyzes m(1)A1408 modification to block the action of structurally diverse aminoglycoside antibiotics. Here, we describe the development of a fluorescence polarization binding assay and its use, together with complementary functional assays,...
Shranjeno v:
| izdano v: | Antimicrob Agents Chemother |
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| Main Authors: | , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society for Microbiology
2017
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5404524/ https://ncbi.nlm.nih.gov/pubmed/28289026 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00077-17 |
| Oznake: |
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