Chromatographic Efficiency and Selectivity in Top-down Proteomics of Histones

Histones are involved in epigenetic control of a wide variety of cellular processes through their multiple post-translational modifications. Their strongly cationic nature makes them challenging to separate with reversed-phase liquid chromatography coupled to mass spectrometry (RPLC-MS), where trifl...

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Bibliographic Details
Published in:J Chromatogr B Analyt Technol Biomed Life Sci
Main Authors: Zhou, Yiyang, Zhang, Ximo, Fornelli, Luca, Compton, Philip D., Kelleher, Neil, Wirth, Mary J.
Format: Artigo
Language:Inglês
Published: 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5404389/
https://ncbi.nlm.nih.gov/pubmed/28076774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jchromb.2016.12.027
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