RyR2-Mediated Ca(2+) Release and Mitochondrial ROS Generation Partake in the Synaptic Dysfunction Caused by Amyloid β Peptide Oligomers

Amyloid β peptide oligomers (AβOs), toxic aggregates with pivotal roles in Alzheimer’s disease, trigger persistent and low magnitude Ca(2+) signals in neurons. We reported previously that these Ca(2+) signals, which arise from Ca(2+) entry and subsequent amplification by Ca(2+) release through ryano...

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Foilsithe in:Front Mol Neurosci
Main Authors: SanMartín, Carol D., Veloso, Pablo, Adasme, Tatiana, Lobos, Pedro, Bruna, Barbara, Galaz, Jose, García, Alejandra, Hartel, Steffen, Hidalgo, Cecilia, Paula-Lima, Andrea C.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Frontiers Media S.A. 2017
Ábhair:
Neuroscience
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5403897/
https://ncbi.nlm.nih.gov/pubmed/28487634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2017.00115
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