Dual bioluminescence and near-infrared fluorescence monitoring to evaluate spherical nucleic acid nanoconjugate activity in vivo

RNA interference (RNAi)-based gene regulation platforms have shown promise as a novel class of therapeutics for the precision treatment of cancer. Techniques in preclinical evaluation of RNAi-based nanoconjugates have yet to allow for optimization of their gene regulatory activity. We have developed...

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Библиографические подробности
Опубликовано в: :Proc Natl Acad Sci U S A
Главные авторы: Sita, Timothy L., Kouri, Fotini M., Hurley, Lisa A., Merkel, Timothy J., Chalastanis, Alexandra, May, Jasmine L., Ghelfi, Serena T., Cole, Lisa E., Cayton, Thomas C., Barnaby, Stacey N., Sprangers, Anthony J., Savalia, Nikunjkumar, James, Charles David, Lee, Andrew, Mirkin, Chad A., Stegh, Alexander H.
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2017
Предметы:
Biological Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5402467/
https://ncbi.nlm.nih.gov/pubmed/28373576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1702736114
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