Spherical Nucleic Acid Nanoparticle Conjugates as an RNAi-Based Therapy for Glioblastoma

Glioblastoma multiforme (GBM) is a neurologically debilitating disease that culminates in death 14 to 16 months after diagnosis. An incomplete understanding of how cataloged genetic aberrations promote therapy resistance, combined with ineffective drug delivery to the central nervous system, has ren...

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Detalhes bibliográficos
Main Authors: Jensen, Samuel A., Day, Emily S., Ko, Caroline H., Hurley, Lisa A., Luciano, Janina P., Kouri, Fotini M., Merkel, Timothy J., Luthi, Andrea J., Patel, Pinal C., Cutler, Joshua I., Daniel, Weston L., Scott, Alexander W., Rotz, Matthew W., Meade, Thomas J., Giljohann, David A., Mirkin, Chad A., Stegh, Alexander H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4017940/
https://ncbi.nlm.nih.gov/pubmed/24174328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3006839
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