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Ribozyme-Spherical Nucleic Acids

Ribozymes are highly structured RNA sequences that can be tailored to recognize and cleave specific stretches of mRNA. Their current therapeutic efficacy remains low due to their large size and structural instability compared to shorter therapeutically relevant RNA such as small interfering RNA (siR...

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Detalles Bibliográficos
Publicado en:J Am Chem Soc
Autores principales: Rouge, Jessica L., Sita, Timothy L., Hao, Liangliang, Kouri, Fotini M., Briley, William E., Stegh, Alexander H., Mirkin, Chad A.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4666730/
https://ncbi.nlm.nih.gov/pubmed/26271335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b07104
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