Dual bioluminescence and near-infrared fluorescence monitoring to evaluate spherical nucleic acid nanoconjugate activity in vivo

RNA interference (RNAi)-based gene regulation platforms have shown promise as a novel class of therapeutics for the precision treatment of cancer. Techniques in preclinical evaluation of RNAi-based nanoconjugates have yet to allow for optimization of their gene regulatory activity. We have developed...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Sita, Timothy L., Kouri, Fotini M., Hurley, Lisa A., Merkel, Timothy J., Chalastanis, Alexandra, May, Jasmine L., Ghelfi, Serena T., Cole, Lisa E., Cayton, Thomas C., Barnaby, Stacey N., Sprangers, Anthony J., Savalia, Nikunjkumar, James, Charles David, Lee, Andrew, Mirkin, Chad A., Stegh, Alexander H.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2017
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5402467/
https://ncbi.nlm.nih.gov/pubmed/28373576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1702736114
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