Dual bioluminescence and near-infrared fluorescence monitoring to evaluate spherical nucleic acid nanoconjugate activity in vivo

RNA interference (RNAi)-based gene regulation platforms have shown promise as a novel class of therapeutics for the precision treatment of cancer. Techniques in preclinical evaluation of RNAi-based nanoconjugates have yet to allow for optimization of their gene regulatory activity. We have developed...

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Publicat a:Proc Natl Acad Sci U S A
Autors principals: Sita, Timothy L., Kouri, Fotini M., Hurley, Lisa A., Merkel, Timothy J., Chalastanis, Alexandra, May, Jasmine L., Ghelfi, Serena T., Cole, Lisa E., Cayton, Thomas C., Barnaby, Stacey N., Sprangers, Anthony J., Savalia, Nikunjkumar, James, Charles David, Lee, Andrew, Mirkin, Chad A., Stegh, Alexander H.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2017
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5402467/
https://ncbi.nlm.nih.gov/pubmed/28373576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1702736114
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