Dual bioluminescence and near-infrared fluorescence monitoring to evaluate spherical nucleic acid nanoconjugate activity in vivo

RNA interference (RNAi)-based gene regulation platforms have shown promise as a novel class of therapeutics for the precision treatment of cancer. Techniques in preclinical evaluation of RNAi-based nanoconjugates have yet to allow for optimization of their gene regulatory activity. We have developed...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Sita, Timothy L., Kouri, Fotini M., Hurley, Lisa A., Merkel, Timothy J., Chalastanis, Alexandra, May, Jasmine L., Ghelfi, Serena T., Cole, Lisa E., Cayton, Thomas C., Barnaby, Stacey N., Sprangers, Anthony J., Savalia, Nikunjkumar, James, Charles David, Lee, Andrew, Mirkin, Chad A., Stegh, Alexander H.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5402467/
https://ncbi.nlm.nih.gov/pubmed/28373576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1702736114
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