Nit1 is a metabolite repair enzyme that hydrolyzes deaminated glutathione

The mammalian gene Nit1 (nitrilase-like protein 1) encodes a protein that is highly conserved in eukaryotes and is thought to act as a tumor suppressor. Despite being ∼35% sequence identical to ω-amidase (Nit2), the Nit1 protein does not hydrolyze efficiently α-ketoglutaramate (a known physiological...

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Bibliografski detalji
Izdano u:Proc Natl Acad Sci U S A
Glavni autori: Peracchi, Alessio, Veiga-da-Cunha, Maria, Kuhara, Tomiko, Ellens, Kenneth W., Paczia, Nicole, Stroobant, Vincent, Seliga, Agnieszka K., Marlaire, Simon, Jaisson, Stephane, Bommer, Guido T., Sun, Jin, Huebner, Kay, Linster, Carole L., Cooper, Arthur J. L., Van Schaftingen, Emile
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2017
Teme:
PNAS Plus
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5402446/
https://ncbi.nlm.nih.gov/pubmed/28373563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1613736114
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