Nit1 is a metabolite repair enzyme that hydrolyzes deaminated glutathione

The mammalian gene Nit1 (nitrilase-like protein 1) encodes a protein that is highly conserved in eukaryotes and is thought to act as a tumor suppressor. Despite being ∼35% sequence identical to ω-amidase (Nit2), the Nit1 protein does not hydrolyze efficiently α-ketoglutaramate (a known physiological...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Peracchi, Alessio, Veiga-da-Cunha, Maria, Kuhara, Tomiko, Ellens, Kenneth W., Paczia, Nicole, Stroobant, Vincent, Seliga, Agnieszka K., Marlaire, Simon, Jaisson, Stephane, Bommer, Guido T., Sun, Jin, Huebner, Kay, Linster, Carole L., Cooper, Arthur J. L., Van Schaftingen, Emile
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2017
Soggetti:
PNAS Plus
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5402446/
https://ncbi.nlm.nih.gov/pubmed/28373563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1613736114
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