Nit1 is a metabolite repair enzyme that hydrolyzes deaminated glutathione

The mammalian gene Nit1 (nitrilase-like protein 1) encodes a protein that is highly conserved in eukaryotes and is thought to act as a tumor suppressor. Despite being ∼35% sequence identical to ω-amidase (Nit2), the Nit1 protein does not hydrolyze efficiently α-ketoglutaramate (a known physiological...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Peracchi, Alessio, Veiga-da-Cunha, Maria, Kuhara, Tomiko, Ellens, Kenneth W., Paczia, Nicole, Stroobant, Vincent, Seliga, Agnieszka K., Marlaire, Simon, Jaisson, Stephane, Bommer, Guido T., Sun, Jin, Huebner, Kay, Linster, Carole L., Cooper, Arthur J. L., Van Schaftingen, Emile
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5402446/
https://ncbi.nlm.nih.gov/pubmed/28373563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1613736114
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