Failure to eliminate a phosphorylated glucose analog leads to neutropenia in patients with G6PT and G6PC3 deficiency

Neutropenia represents an important problem in patients with genetic deficiency in either the glucose-6-phosphate transporter of the endoplasmic reticulum (G6PT/SLC37A4) or G6PC3, an endoplasmic reticulum phosphatase homologous to glucose-6-phosphatase. While affected granulocytes show reduced gluco...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Proc Natl Acad Sci U S A
Egile Nagusiak: Veiga-da-Cunha, Maria, Chevalier, Nathalie, Stephenne, Xavier, Defour, Jean-Philippe, Paczia, Nicole, Ferster, Alina, Achouri, Younes, Dewulf, Joseph P., Linster, Carole L., Bommer, Guido T., Van Schaftingen, Emile
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2019
Gaiak:
PNAS Plus
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6347702/
https://ncbi.nlm.nih.gov/pubmed/30626647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1816143116
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