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Mice exclusively expressing the short isoform of Smad2 develop normally and are viable and fertile
Smad2 and Smad3 are closely related effectors of TGFβ/Nodal/Activin-related signaling. Smad3 mutant mice develop normally, whereas Smad2 plays an essential role in patterning the embryonic axis and specification of definitive endoderm. Alternative splicing of Smad2 exon 3 gives rise to two distinct...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Cold Spring Harbor Laboratory Press
2005
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC540233/ https://ncbi.nlm.nih.gov/pubmed/15630024 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1243205 |
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