Mice exclusively expressing the short isoform of Smad2 develop normally and are viable and fertile

Smad2 and Smad3 are closely related effectors of TGFβ/Nodal/Activin-related signaling. Smad3 mutant mice develop normally, whereas Smad2 plays an essential role in patterning the embryonic axis and specification of definitive endoderm. Alternative splicing of Smad2 exon 3 gives rise to two distinct...

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Bibliografske podrobnosti
Main Authors: Dunn, N. Ray, Koonce, Chad H., Anderson, Dorian C., Islam, Ayesha, Bikoff, Elizabeth K., Robertson, Elizabeth J.
Format: Artigo
Jezik:Inglês
Izdano: Cold Spring Harbor Laboratory Press 2005
Teme:
Research Papers
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC540233/
https://ncbi.nlm.nih.gov/pubmed/15630024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1243205
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