Mice develop normally in the absence of Smad4 nucleocytoplasmic shuttling

Smad4 in partnership with R-Smads (receptor-regulated Smads) activates TGF-β (transforming growth factor-β)-dependent signalling pathways essential for early mouse development. Smad4 null embryos die shortly after implantation due to severe defects in cell proliferation and visceral endoderm differe...

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Detalhes bibliográficos
Main Authors: Biondi, Christine A., Das, Debipriya, Howell, Michael, Islam, Ayesha, Bikoff, Elizabeth K., Hill, Caroline S., Robertson, Elizabeth J.
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2007
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1868808/
https://ncbi.nlm.nih.gov/pubmed/17300215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20061830
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