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Mice develop normally in the absence of Smad4 nucleocytoplasmic shuttling
Smad4 in partnership with R-Smads (receptor-regulated Smads) activates TGF-β (transforming growth factor-β)-dependent signalling pathways essential for early mouse development. Smad4 null embryos die shortly after implantation due to severe defects in cell proliferation and visceral endoderm differe...
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| Главные авторы: | , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Portland Press Ltd.
2007
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1868808/ https://ncbi.nlm.nih.gov/pubmed/17300215 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20061830 |
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