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Fluid shear stress induces upregulation of COX-2 and PGI(2) release in endothelial cells via a pathway involving PECAM-1, PI3K, FAK, and p38

Vascular endothelial cells play an important role in the regulation of vascular function in response to mechanical stimuli in both healthy and diseased states. Prostaglandin I(2) (PGI(2)) is an important antiatherogenic prostanoid and vasodilator produced in endothelial cells through the action of t...

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Bibliografiske detaljer
Udgivet i:Am J Physiol Heart Circ Physiol
Main Authors: Russell-Puleri, Sparkle, dela Paz, Nathaniel G., Adams, Diana, Chattopadhyay, Mitali, Cancel, Limary, Ebong, Eno, Orr, A. Wayne, Frangos, John A., Tarbell, John M.
Format: Artigo
Sprog:Inglês
Udgivet: American Physiological Society 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5402016/
https://ncbi.nlm.nih.gov/pubmed/28011582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00035.2016
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