Fluid shear stress induces upregulation of COX-2 and PGI(2) release in endothelial cells via a pathway involving PECAM-1, PI3K, FAK, and p38

Vascular endothelial cells play an important role in the regulation of vascular function in response to mechanical stimuli in both healthy and diseased states. Prostaglandin I(2) (PGI(2)) is an important antiatherogenic prostanoid and vasodilator produced in endothelial cells through the action of t...

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Detalhes bibliográficos
Publicado no:Am J Physiol Heart Circ Physiol
Main Authors: Russell-Puleri, Sparkle, dela Paz, Nathaniel G., Adams, Diana, Chattopadhyay, Mitali, Cancel, Limary, Ebong, Eno, Orr, A. Wayne, Frangos, John A., Tarbell, John M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5402016/
https://ncbi.nlm.nih.gov/pubmed/28011582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00035.2016
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