Fluid shear stress induces upregulation of COX-2 and PGI(2) release in endothelial cells via a pathway involving PECAM-1, PI3K, FAK, and p38

Vascular endothelial cells play an important role in the regulation of vascular function in response to mechanical stimuli in both healthy and diseased states. Prostaglandin I(2) (PGI(2)) is an important antiatherogenic prostanoid and vasodilator produced in endothelial cells through the action of t...

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Vydáno v:Am J Physiol Heart Circ Physiol
Hlavní autoři: Russell-Puleri, Sparkle, dela Paz, Nathaniel G., Adams, Diana, Chattopadhyay, Mitali, Cancel, Limary, Ebong, Eno, Orr, A. Wayne, Frangos, John A., Tarbell, John M.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2017
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5402016/
https://ncbi.nlm.nih.gov/pubmed/28011582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00035.2016
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