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Oxidized phagosomal NOX2 complex is replenished from lysosomes
In dendritic cells, the NADPH oxidase 2 complex (NOX2) is recruited to the phagosomal membrane during antigen uptake. NOX2 produces reactive oxygen species (ROS) in the lumen of the phagosome that kill ingested pathogens, delay antigen breakdown and alter the peptide repertoire for presentation to T...
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| Pubblicato in: | J Cell Sci |
|---|---|
| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
The Company of Biologists Ltd
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5399780/ https://ncbi.nlm.nih.gov/pubmed/28202687 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.196931 |
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