Oxidized phagosomal NOX2 complex is replenished from lysosomes

In dendritic cells, the NADPH oxidase 2 complex (NOX2) is recruited to the phagosomal membrane during antigen uptake. NOX2 produces reactive oxygen species (ROS) in the lumen of the phagosome that kill ingested pathogens, delay antigen breakdown and alter the peptide repertoire for presentation to T...

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Bibliografski detalji
Izdano u:J Cell Sci
Glavni autori: Dingjan, Ilse, Linders, Peter T. A., van den Bekerom, Luuk, Baranov, Maksim V., Halder, Partho, ter Beest, Martin, van den Bogaart, Geert
Format: Artigo
Jezik:Inglês
Izdano: The Company of Biologists Ltd 2017
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5399780/
https://ncbi.nlm.nih.gov/pubmed/28202687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.196931
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