Oxidized phagosomal NOX2 complex is replenished from lysosomes

In dendritic cells, the NADPH oxidase 2 complex (NOX2) is recruited to the phagosomal membrane during antigen uptake. NOX2 produces reactive oxygen species (ROS) in the lumen of the phagosome that kill ingested pathogens, delay antigen breakdown and alter the peptide repertoire for presentation to T...

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Publicat a:J Cell Sci
Autors principals: Dingjan, Ilse, Linders, Peter T. A., van den Bekerom, Luuk, Baranov, Maksim V., Halder, Partho, ter Beest, Martin, van den Bogaart, Geert
Format: Artigo
Idioma:Inglês
Publicat: The Company of Biologists Ltd 2017
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5399780/
https://ncbi.nlm.nih.gov/pubmed/28202687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.196931
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