Serial deletion reveals structural basis and stability for the core enzyme activity of human glutaminase 1 isoforms: relevance to excitotoxic neurodegeneration

BACKGROUND: Glutaminase 1 is a phosphate-activated metabolic enzyme that catalyzes the first step of glutaminolysis, which converts glutamine into glutamate. Glutamate is the major neurotransmitter of excitatory synapses, executing important physiological functions in the central nervous system. The...

Ful tanımlama

Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Transl Neurodegener
Asıl Yazarlar: Li, Yuju, Peer, Justin, Zhao, Runze, Xu, Yinghua, Wu, Beiqing, Wang, Yi, Tian, Changhai, Huang, Yunlong, Zheng, Jialin
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BioMed Central 2017
Konular:
Research
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5399437/
https://ncbi.nlm.nih.gov/pubmed/28439409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40035-017-0080-x
Etiketler: Etiketle
Etiket eklenmemiş, İlk siz ekleyin!

Benzer Materyaller