Serial deletion reveals structural basis and stability for the core enzyme activity of human glutaminase 1 isoforms: relevance to excitotoxic neurodegeneration

BACKGROUND: Glutaminase 1 is a phosphate-activated metabolic enzyme that catalyzes the first step of glutaminolysis, which converts glutamine into glutamate. Glutamate is the major neurotransmitter of excitatory synapses, executing important physiological functions in the central nervous system. The...

Full beskrivning

Sparad:
Bibliografiska uppgifter
I publikationen:Transl Neurodegener
Huvudupphovsmän: Li, Yuju, Peer, Justin, Zhao, Runze, Xu, Yinghua, Wu, Beiqing, Wang, Yi, Tian, Changhai, Huang, Yunlong, Zheng, Jialin
Materialtyp: Artigo
Språk:Inglês
Publicerad: BioMed Central 2017
Ämnen:
Research
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5399437/
https://ncbi.nlm.nih.gov/pubmed/28439409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40035-017-0080-x
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk