Glutaminase-containing microvesicles from HIV-1-infected macrophages and immune-activated microglia induce neurotoxicity

BACKGROUND: HIV-1-infected and/or immune-activated microglia and macrophages are pivotal in the pathogenesis of HIV-1-associated neurocognitive disorders (HAND). Glutaminase, a metabolic enzyme that facilitates glutamate generation, is upregulated and may play a pathogenic role in HAND. Our previous...

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Veröffentlicht in:Mol Neurodegener
Hauptverfasser: Wu, Beiqing, Huang, Yunlong, Braun, Alexander L., Tong, Zenghan, Zhao, Runze, Li, Yuju, Liu, Fang, Zheng, Jialin C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2015
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4635976/
https://ncbi.nlm.nih.gov/pubmed/26546362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-015-0058-z
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