Serial deletion reveals structural basis and stability for the core enzyme activity of human glutaminase 1 isoforms: relevance to excitotoxic neurodegeneration

BACKGROUND: Glutaminase 1 is a phosphate-activated metabolic enzyme that catalyzes the first step of glutaminolysis, which converts glutamine into glutamate. Glutamate is the major neurotransmitter of excitatory synapses, executing important physiological functions in the central nervous system. The...

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Detalhes bibliográficos
Publicado no:Transl Neurodegener
Main Authors: Li, Yuju, Peer, Justin, Zhao, Runze, Xu, Yinghua, Wu, Beiqing, Wang, Yi, Tian, Changhai, Huang, Yunlong, Zheng, Jialin
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5399437/
https://ncbi.nlm.nih.gov/pubmed/28439409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40035-017-0080-x
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