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CrkII regulates focal adhesion kinase activation by making a complex with Crk-associated substrate, p130(Cas)
CrkII is an adaptor protein possessing oncogenic potential despite the lack of an enzymatic domain. We investigated here the physiological functions of CrkII by studying its ability to induce anchorage-independent cell growth. We found that inhibition or null mutation of focal adhesion kinase (FAK)...
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| Publicado no: | Proc Natl Acad Sci U S A |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC539787/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15598735/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0408413102 |
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