Identification of Novel Crk-associated Substrate (p130(Cas)) Variants with Functionally Distinct Focal Adhesion Kinase Binding Activities

Elevated levels of p130(Cas) (Crk-associated substrate)/BCAR1 (breast cancer antiestrogen resistance 1 gene) are associated with aggressiveness of breast tumors. Following phosphorylation of its substrate domain, p130(Cas) promotes the integration of protein complexes involved in multiple signaling...

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Publicado en:J Biol Chem
Autores principales: Kumbrink, Joerg, Soni, Shefali, Laumbacher, Barbara, Loesch, Barbara, Kirsch, Kathrin H.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2015
Materias:
Cell Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4424356/
https://ncbi.nlm.nih.gov/pubmed/25805500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.649947
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