Cathepsin H–Mediated Degradation of HDAC4 for Matrix Metalloproteinase Expression in Hepatic Stellate Cells: Implications of Epigenetic Suppression of Matrix Metalloproteinases in Fibrosis through Stabilization of Class IIa Histone Deacetylases

In three-dimensional extracellular matrix, mesenchymal cells including hepatic stellate cells (HSCs) gain the ability to express matrix metalloproteinases (MMPs) on injury signals. In contrast, in myofibroblastic HSCs in fibrotic liver, many MMP genes are silenced into an epigenetically nonpermissiv...

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Detalhes bibliográficos
Publicado no:Am J Pathol
Main Authors: Yang, Zemin, Liu, Yu, Qin, Lan, Wu, Pengfei, Xia, Zanxian, Luo, Mei, Zeng, Yilan, Tsukamoto, Hidekazu, Ju, Zongyun, Su, Danmei, Kang, Han, Xiao, Zhixiong, Zheng, Sujun, Duan, Zhongping, Hu, Richard, Wang, Qiang, Pandol, Stephen J., Han, Yuan-Ping
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2017
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5397721/
https://ncbi.nlm.nih.gov/pubmed/28157489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2016.12.001
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