Cathepsin H–Mediated Degradation of HDAC4 for Matrix Metalloproteinase Expression in Hepatic Stellate Cells: Implications of Epigenetic Suppression of Matrix Metalloproteinases in Fibrosis through Stabilization of Class IIa Histone Deacetylases

In three-dimensional extracellular matrix, mesenchymal cells including hepatic stellate cells (HSCs) gain the ability to express matrix metalloproteinases (MMPs) on injury signals. In contrast, in myofibroblastic HSCs in fibrotic liver, many MMP genes are silenced into an epigenetically nonpermissiv...

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Detalles Bibliográficos
Publicado en:Am J Pathol
Autores principales: Yang, Zemin, Liu, Yu, Qin, Lan, Wu, Pengfei, Xia, Zanxian, Luo, Mei, Zeng, Yilan, Tsukamoto, Hidekazu, Ju, Zongyun, Su, Danmei, Kang, Han, Xiao, Zhixiong, Zheng, Sujun, Duan, Zhongping, Hu, Richard, Wang, Qiang, Pandol, Stephen J., Han, Yuan-Ping
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Investigative Pathology 2017
Materias:
Regular Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5397721/
https://ncbi.nlm.nih.gov/pubmed/28157489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2016.12.001
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