Cathepsin H–Mediated Degradation of HDAC4 for Matrix Metalloproteinase Expression in Hepatic Stellate Cells: Implications of Epigenetic Suppression of Matrix Metalloproteinases in Fibrosis through Stabilization of Class IIa Histone Deacetylases

In three-dimensional extracellular matrix, mesenchymal cells including hepatic stellate cells (HSCs) gain the ability to express matrix metalloproteinases (MMPs) on injury signals. In contrast, in myofibroblastic HSCs in fibrotic liver, many MMP genes are silenced into an epigenetically nonpermissiv...

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Bibliographische Detailangaben
Veröffentlicht in:Am J Pathol
Hauptverfasser: Yang, Zemin, Liu, Yu, Qin, Lan, Wu, Pengfei, Xia, Zanxian, Luo, Mei, Zeng, Yilan, Tsukamoto, Hidekazu, Ju, Zongyun, Su, Danmei, Kang, Han, Xiao, Zhixiong, Zheng, Sujun, Duan, Zhongping, Hu, Richard, Wang, Qiang, Pandol, Stephen J., Han, Yuan-Ping
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Investigative Pathology 2017
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Regular Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5397721/
https://ncbi.nlm.nih.gov/pubmed/28157489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2016.12.001
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