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Epigenetic Repression of Matrix Metalloproteinases in Myofibroblastic Hepatic Stellate Cells through Histone Deacetylases 4: Implication in Tissue Fibrosis

Matrix metalloproteinases (MMPs), which are highly expressed in acute injury, are progressively repressed or silenced in fibrotic liver, favoring extracellular matrix accumulation, while the underlying mechanism is largely unknown. Similarly, normal/quiescent hepatic stellate cells (HSCs) express hi...

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Bibliografiske detaljer
Main Authors: Qin, Lan, Han, Yuan-Ping
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Investigative Pathology 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2947286/
https://ncbi.nlm.nih.gov/pubmed/20847282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.100011
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