Cathepsin H–Mediated Degradation of HDAC4 for Matrix Metalloproteinase Expression in Hepatic Stellate Cells: Implications of Epigenetic Suppression of Matrix Metalloproteinases in Fibrosis through Stabilization of Class IIa Histone Deacetylases

In three-dimensional extracellular matrix, mesenchymal cells including hepatic stellate cells (HSCs) gain the ability to express matrix metalloproteinases (MMPs) on injury signals. In contrast, in myofibroblastic HSCs in fibrotic liver, many MMP genes are silenced into an epigenetically nonpermissiv...

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Udgivet i:Am J Pathol
Main Authors: Yang, Zemin, Liu, Yu, Qin, Lan, Wu, Pengfei, Xia, Zanxian, Luo, Mei, Zeng, Yilan, Tsukamoto, Hidekazu, Ju, Zongyun, Su, Danmei, Kang, Han, Xiao, Zhixiong, Zheng, Sujun, Duan, Zhongping, Hu, Richard, Wang, Qiang, Pandol, Stephen J., Han, Yuan-Ping
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Investigative Pathology 2017
Fag:
Regular Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5397721/
https://ncbi.nlm.nih.gov/pubmed/28157489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2016.12.001
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