Comprehensive evaluation of genome-wide 5-hydroxymethylcytosine profiling approaches in human DNA

BACKGROUND: The discovery that 5-methylcytosine (5mC) can be oxidized to 5-hydroxymethylcytosine (5hmC) by the ten-eleven translocation (TET) proteins has prompted wide interest in the potential role of 5hmC in reshaping the mammalian DNA methylation landscape. The gold-standard bisulphite conversio...

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Vydáno v:Epigenetics Chromatin
Hlavní autoři: Skvortsova, Ksenia, Zotenko, Elena, Luu, Phuc-Loi, Gould, Cathryn M., Nair, Shalima S., Clark, Susan J., Stirzaker, Clare
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2017
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5397694/
https://ncbi.nlm.nih.gov/pubmed/28428825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13072-017-0123-7
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