Identification of small-molecule antagonists that inhibit an activator:coactivator interaction

Phosphorylation of the cAMP response element binding protein (CREB) at Ser-133 in response to hormonal stimuli triggers cellular gene expression via the recruitment of the histone acetylase coactivator paralogs CREB binding protein (CBP) and p300 to the promoter. The NMR structure of the CREB:CBP co...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Best, Jennifer L., Amezcua, Carlos A., Mayr, Bernhard, Flechner, Lawrence, Murawsky, Christopher M., Emerson, Beverly, Zor, Tsaffrir, Gardner, Kevin H., Montminy, Marc
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2004
Gaiak:
Biological Sciences
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC539725/
https://ncbi.nlm.nih.gov/pubmed/15585582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0406374101
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