Identification of small-molecule antagonists that inhibit an activator:coactivator interaction

Phosphorylation of the cAMP response element binding protein (CREB) at Ser-133 in response to hormonal stimuli triggers cellular gene expression via the recruitment of the histone acetylase coactivator paralogs CREB binding protein (CBP) and p300 to the promoter. The NMR structure of the CREB:CBP co...

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Bibliografiske detaljer
Main Authors: Best, Jennifer L., Amezcua, Carlos A., Mayr, Bernhard, Flechner, Lawrence, Murawsky, Christopher M., Emerson, Beverly, Zor, Tsaffrir, Gardner, Kevin H., Montminy, Marc
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2004
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC539725/
https://ncbi.nlm.nih.gov/pubmed/15585582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0406374101
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