Editing of misaminoacylated tRNA controls the sensitivity of amino acid stress responses in Saccharomyces cerevisiae

Amino acid starvation activates the protein kinase Gcn2p, leading to changes in gene expression and translation. Gcn2p is activated by deacylated tRNA, which accumulates when tRNA aminoacylation is limited by lack of substrates or inhibition of synthesis. Pairing of amino acids and deacylated tRNAs...

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Bibliografiske detaljer
Udgivet i:Nucleic Acids Res
Main Authors: Mohler, Kyle, Mann, Rebecca, Bullwinkle, Tammy J., Hopkins, Kyle, Hwang, Lin, Reynolds, Noah M., Gassaway, Brandon, Aerni, Hans-Rudolf, Rinehart, Jesse, Polymenis, Michael, Faull, Kym, Ibba, Michael
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2017
Fag:
Nucleic Acid Enzymes
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5397148/
https://ncbi.nlm.nih.gov/pubmed/28168297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx077
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