The mechanism of β-N-methylamino-l-alanine inhibition of tRNA aminoacylation and its impact on misincorporation

β-N-methylamino-l-alanine (BMAA) is a nonproteinogenic amino acid that has been associated with neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and Alzheimer's disease (AD). BMAA has been found in human protein extracts; however, the mechanism by which it enters the pr...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Biol Chem
Prif Awduron: Han, Nien-Ching, Bullwinkle, Tammy J., Loeb, Kaeli F., Faull, Kym F., Mohler, Kyle, Rinehart, Jesse, Ibba, Michael
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2020
Pynciau:
Protein Synthesis and Degradation
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6996898/
https://ncbi.nlm.nih.gov/pubmed/31862734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.011714
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