Phosphatidylcholine-specific phospholipase C inhibition down- regulates CXCR4 expression and interferes with proliferation, invasion and glycolysis in glioma cells

BACKGROUND: The chemokine receptor CXCR4 plays a crucial role in tumors, including glioblastoma multiforme (GBM), the most aggressive glioma. Phosphatidylcholine-specific phospholipase C (PC-PLC), a catabolic enzyme of PC metabolism, is involved in several aspects of cancer biology and its inhibitio...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:PLoS One
Prif Awduron: Mercurio, Laura, Cecchetti, Serena, Ricci, Alessandro, Pacella, Aurora, Cigliana, Giovanni, Bozzuto, Giuseppina, Podo, Franca, Iorio, Egidio, Carpinelli, Giulia
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2017
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5397108/
https://ncbi.nlm.nih.gov/pubmed/28423060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0176108
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