Activation of Phosphatidylcholine-Specific Phospholipase C in Breast and Ovarian Cancer: Impact on MRS-Detected Choline Metabolic Profile and Perspectives for Targeted Therapy

Elucidation of molecular mechanisms underlying the aberrant phosphatidylcholine cycle in cancer cells plays in favor of the use of metabolic imaging in oncology and opens the way for designing new targeted therapies. The anomalous choline metabolic profile detected in cancer by magnetic resonance sp...

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Veröffentlicht in:Front Oncol
Hauptverfasser: Podo, Franca, Paris, Luisa, Cecchetti, Serena, Spadaro, Francesca, Abalsamo, Laura, Ramoni, Carlo, Ricci, Alessandro, Pisanu, Maria Elena, Sardanelli, Francesco, Canese, Rossella, Iorio, Egidio
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2016
Schlagworte:
Oncology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4969288/
https://ncbi.nlm.nih.gov/pubmed/27532027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2016.00171
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