Phosphatidylcholine-specific phospholipase C inhibition down- regulates CXCR4 expression and interferes with proliferation, invasion and glycolysis in glioma cells

BACKGROUND: The chemokine receptor CXCR4 plays a crucial role in tumors, including glioblastoma multiforme (GBM), the most aggressive glioma. Phosphatidylcholine-specific phospholipase C (PC-PLC), a catabolic enzyme of PC metabolism, is involved in several aspects of cancer biology and its inhibitio...

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Udgivet i:PLoS One
Main Authors: Mercurio, Laura, Cecchetti, Serena, Ricci, Alessandro, Pacella, Aurora, Cigliana, Giovanni, Bozzuto, Giuseppina, Podo, Franca, Iorio, Egidio, Carpinelli, Giulia
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5397108/
https://ncbi.nlm.nih.gov/pubmed/28423060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0176108
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