Inhibition of phosphatidylcholine-specific phospholipase C downregulates HER2 overexpression on plasma membrane of breast cancer cells

INTRODUCTION: Overexpression on plasma membrane of human epidermal growth factor receptor 2 (HER2) is reported in 25% to 30% of breast cancers. Heterodimer formation with cognate members of the epidermal growth factor receptor (EGFR) family, such as HER3 and EGFR, activates abnormal cell-signalling...

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Main Authors: Paris, Luisa, Cecchetti, Serena, Spadaro, Francesca, Abalsamo, Laura, Lugini, Luana, Pisanu, Maria Elena, Iorio, Egidio, Natali, Pier Giorgio, Ramoni, Carlo, Podo, Franca
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2010
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2917016/
https://ncbi.nlm.nih.gov/pubmed/20462431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr2575
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