RyR(2)(R420Q) catecholaminergic polymorphic ventricular tachycardia mutation induces bradycardia by disturbing the coupled clock pacemaker mechanism

Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a lethal genetic arrhythmia that manifests syncope or sudden death in children and young adults under stress conditions. CPVT patients often present bradycardia and sino-atrial node (SAN) dysfunction. However, the mechanism remains uncl...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:JCI Insight
Main Authors: Wang, Yue Yi, Mesirca, Pietro, Marqués-Sulé, Elena, Zahradnikova, Alexandra, Villejoubert, Olivier, D’Ocon, Pilar, Ruiz, Cristina, Domingo, Diana, Zorio, Esther, Mangoni, Matteo E., Benitah, Jean-Pierre, Gómez, Ana María
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2017
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5396513/
https://ncbi.nlm.nih.gov/pubmed/28422759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.91872
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares