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Synthetic lethality: emerging targets and opportunities in melanoma

Great progress has been made in the treatment of melanoma through use of targeted therapies and immunotherapy. One approach that has not been fully explored is synthetic lethality, which exploits somatically acquired changes, usually driver mutations, to specifically kill tumour cells. We outline th...

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Detalhes bibliográficos
Publicado no:Pigment Cell Melanoma Res
Main Authors: Thompson, Nicola, Adams, David J., Ranzani, Marco
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5396340/
https://ncbi.nlm.nih.gov/pubmed/28097822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/pcmr.12573
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