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Targeting cell cycle regulation via the G2-M checkpoint for synthetic lethality in melanoma
Disruption of cell cycle checkpoints has been well established as a hallmark of cancer. In particular, the G1-S transition mediated by the cyclin D-cyclin-dependent kinase 4/6 (CDK4/6) pathway is dysregulated in more than 90% of melanoma cases. Therefore, tumor cells mainly rely on the G2-M checkpoi...
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| Vydáno v: | Cell Cycle |
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| Hlavní autoři: | , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Taylor & Francis
2021
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8208119/ https://ncbi.nlm.nih.gov/pubmed/33966611 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2021.1922806 |
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