GENE-12. EMERGING PRINCIPLES OF SYNTHETIC LETHALITY IN GLIOBLASTOMA

Synthetic lethality occurs when mutations in two otherwise non-essential genes are combined to cause lethality. Because cancer is a disease of genetic alteration, synthetic lethality has been heralded as a method to identity candidate therapeutic targets, e.g., where a target gene could be “syntheti...

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Publicado no:Neuro Oncol
Main Authors: Hoellerbauer, Pia, Arora, Sonali, Feldman, Heather, Carter, Lucas, Girard, Emily J, Corrin, Philip, Olson, James M, Paddison, Patrick
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5693033/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.387
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