DN-01 BYPASSING GLIOBLASTOMA RESISTANCE TO EGFR INHIBITORS BY SYNTHETIC LETHALITY

Clinical efficacy of EGFR inhibitors (EGFRi) in glioblastoma patients has been limited by a multitude of resistance mechanisms. We hypothesized that these mechanisms emerge upstream of the interface between EGFR signaling and fundamental cellular processes, such as DNA damage response (DDR), without...

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Main Authors: Chen, Clark, Shen, Ying, Nitta, Masayuki, Futalan, Diahnn, Taich, Zack, Treiber, Jeffrey, Stevens, Deanna, Chen, Hong-Zhuan, Carter, Bob, Esashi, Fumiko, Sarkaria, Jann, Furnari, Frank, Cavenee, Webster, Desai, Arshad
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4218028/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou245.1
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