PPARγ agonists negatively regulate αIIbβ3 integrin outside‐in signaling and platelet function through up‐regulation of protein kinase A activity

ESSENTIALS: peroxisome proliferator‐activated receptor γ (PPARγ) agonists inhibit platelet function. PPARγ agonists negatively regulate outside‐in signaling via integrin αIIbβ3. PPARγ agonists disrupt the interaction of Gα13 with integrin β3. This is attributed to an upregulation of protein kinase A...

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Bibliographic Details
Published in:J Thromb Haemost
Main Authors: Unsworth, A. J., Kriek, N., Bye, A. P., Naran, K., Sage, T., Flora, G. D., Gibbins, J. M.
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5396324/
https://ncbi.nlm.nih.gov/pubmed/27896950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jth.13578
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